Origami with DNA for study of T-cells 🧫🧬🧪
Researchers at TU Wien used artificial membrane along with DNA origami technique to be able to study the interaction between the T-cells and the antigen-presenting cells in detail. There was some evidence that the spatial distance between antigens plays an important role in T-cell activation. The researchers built a rectangular DNA platform to which one can fix an antigen. By cleverly designing single strands that only fit together in certain sections, they connected several double helices with each other and thus created complicated structures. This DNA rectangle was placed on the artificial membrane and it moved there like a raft. This technique is called DNA origami.