University of Texas Southwestern

University of Texas Southwestern Newsroom
T Cells to Fight Malignant Tumors Even After Their Exhaustion by Deleting a Specific Gene πŸ§¬πŸ”¬πŸ’‰

CD8+ T Cells often called as the Cytotoxic T Lymphocytes are very important for the tumor surveillance and immune defense responses. According to a new study led by UT Southwestern Researchers, CD8+ T cells can continue to fight malignant tumors by eliminating a single gene called Cbl-b, which is more upregulated in the exhausted cells. This can demonstrate a new way to fight cancer through body's immune system.

Potential Treatment for an Aggressive Form of Lung Cancer πŸ’ŠπŸ¦ πŸ§‘β€πŸ”¬

At the Children’s Medical Center Research Institute at UT Southwestern, researchers have discovered a new metabolic vulnerability in a highly aggressive form of non-small cell lung cancer. The findings could pave the way for new treatments for patients with mutations in the genes KRAS and LKB1. Tumors containing these mutations, known as KL tumors, have poor outcomes and often do not respond to immunotherapy.


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