Nature Communications is a peer-reviewed, open access, scientific journal that covers the natural sciences, including physics, chemistry, earth sciences, medicine, and biology.
Nanoparticle Influenza Immunogens Provide Broader Protection 💉🦠🔬
Researchers primarily from the National Institute of Health (NIH) and University of Washington designed a nanoparticle vaccine to elicit stem-directed neutralizing antibodies. They are aiming to develop a universal flu vaccine and hope that the nanoparticle immunogen can play a large role in its development.
Non-nutritive Sweeteners May Promote Antibiotic Resistance 🦠💊🧬
A team of researchers from The University of Queensland investigated if alternative sweeteners promoted plasmid-mediated conjugative transfer in both environmental and clinical settings.
Researchers Create Lab-Grown Brain Using CRISPR 🧫🧠🧬
Researchers from the University of Basel in Switzerland created small brain-like “organoids” with gene variants from human relatives, Neanderthals and Denisovans. The organoids were made by engineering human stem cells with genes that were common to Neanderthals and humans.
TALEN Gains Traction In Gene Editing After Outperforming CRISPR 🧬🔬🧑🔬
Researchers from University of Illinois at Urbana-Champaign (UIUC) tested the gene editing efficiency of TALEN and CRISPR on heterochromatin, allowing some researchers to argue that it can be a better technique for hard-to-edit regions of the genome.
Researchers Design Synthetic Phages to Tackle Antibiotic Resistance🔬💉🧬🦠
Antibiotic resistance is one of the major concerns in the world of medicine and pharmacology. Antibiotic resistance is a phenomenon where microbes develop mechanisms that protect them from the effects of an antimicrobial agent. In a time where antibiotic resistance is becoming a major problem, genetically engineered bacteriophages are emerging as a promising therapeutic approach to deal with this problem. This innovative use of phages to treat bacterial infections (phage therapy) was conceived almost a century back by Felix d'Herelle however it's real power emerged only recently due to the rise of multi-antibiotic resistant pathogens.
Androgen Therapy For Breast Cancer Shows Promise In Preliminary Study 🎀 🧫 💊
Researchers from Adelaide Medical School in Australia studied the effect of androgen-receptor activating drugs on tumor growth. Using mice with implanted tumors from breast cancer patients, the team concluded that androgen therapy could be a potential therapeutic to fight breast cancer.
InStrain: The New Genetic Analysis Program that Detects Differences between Familial Microbial Germ Lines🦠🧬🧪
Previous technologies, such a 16s RNA, have been used as a means to analyze the biodiversity of the microbiome. The detection of genotypic and phenotypic variation among microbial cells is vital when diagnosing and treating most diseases. InStrain is a new genetic analysis program that uses previously obtained metagenomic data to detect phenotypic differences between microbial cell germ lines.
Scientists Use CRISPR to Program Living Cells to Store Data 🧬🧫💽
Researchers from the Wang Lab in Columbia University Medical School developed a strategy to encode digital data into the genomes of living cells without in-vitro DNA synthesis. Data recording in vivo by electrical stimulation (DRIVES) aims to use electrical signals to essentially “copy and paste” code directly from a computer to living cells.
Novel Drug Discovery Strategy Expands Knowledge of “Undruggable” Diseases🦠🧬💊
Researchers from the The University of Hong Kong in collaboration with Chongqing University and Second Military Medical University developed a novel method to discover drugs for certain diseases by targeting membrane proteins.
New Class of Antibiotics Active Against a Wide Range of Bacteria 🦠💊 🧫
Researchers from Wistar Institute uncovered a class of antibodies that can antimicrobial resistance (AMR). Unlike other types of antibodies, they newly discovered ones combine direct antibiotic killing of pan drug-resistant bacterial pathogens with a simultaneous rapid immune response.